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Non-Opioid Options for Pain Management – Patient and Family Resources

Not all pain management requires the use of opioid medication. See below for patient-focused information on evidence-based, non-opioid treatment options that can be considered in treating pain.

Please note: The content in this toolkit is for your information. It is not intended to substitute for the medical expertise and advice of your health care provider(s). We encourage you to speak with your health care provider before making any decisions about treatment or care. The mention of any products, services, or therapies are informational and not necessarily endorsed by the makers of this toolkit.

  • Opioids are not recommended as the first-line or routine therapy for chronic pain.
  • Non-pharmacologic therapy and non-opioid pharmacologic therapy are preferred for chronic pain.
  • If opioids are used, they should be combined with non-pharmacologic therapy and non-opioid pharmacologic therapy, as appropriate.


  • Non-pharmacological therapies (non-medication treatments): Referring to therapies that do not involve drugs.
  • Non-opioid pharmacological treatments (medication treatments): Referring to non-opioid pain medications.

Non-Opioid Treatment Options

Chronic pain: Medical decisions

  • Learn about the risks and benefits of common pain medications so that you can make safe choices as you seek your solution.

Safely and Effectively Managing Pain Without Opioids

  • This CDC guide for patients highlights non-opioid options for pain management and provides tips for developing a pain management plan.

Treatment of Chronic Pain Moving Beyond Opioids

  • Access this PDF to learn about the management of chronic pain using a stepwise approach.

Summary of Non-Opioid Treatments



Non-Opioid Treatments for Pain: Patient Table

  • This table contains information for patients on different non-opioid pain management options.

For more information on non-opioid treatment options, tailored toward providers: